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A regional oxygen delivery system (RODS) would use a series of oxygen carriers to provide oxygen enriched blood to specific areas of the body. A preliminary investigation of a single RODS was carried out using the rabbit model. Twenty-four rabbits were allocated to six groups. Three groups were given blood from animals that had been hyperventilated and oxygenated using a RODS for 30 min (first and second experimental groups), whereas the third group was given blood from animals that had been blood warmed and oxygenated by convection using a RODS (third experimental group). Animals in the last experimental group (control) were given blood that was not oxygenated or blood warmed or oxygenated. After 10 min of recovery, left ventricular (LV) function was assessed by measuring pressure-rate products (dP/dtmax and dP/dtmin) and LV hemodynamics. In the second experimental group, heart rate increased significantly from baseline and the pressure-rate products decreased. Compared with the control group, there was a significant reduction in the dP/dtmin in the first experimental group. These results indicate that there was an improvement in LV function with the introduction of an oxygen-carrying medium into the circulation. No significant differences in the LV pressure-rate products were detected between the first and second experimental groups. These results indicate that a reduction in the intrinsic inotropic state of the myocardium occurred.Q:

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